Mediamatic is easy to reach by bike, public transport, or by car (but don't forget to buy a parking ticket)
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Mediamatic is located in the Van Gendthallen, with the entrance on the quay-side. The Van Gendthallen are situated on Oostenburgereiland (the former Stork factory yard), east of Amsterdam Central Station. There are a few ways you can access the island. Once you're in, follow the trail of pink birdhouses attached to trees and lampposts. The birdhouses lead the way to Mediamatic.
If you're coming from the Pietheinkade and Panamalaan (SBS, Panama, tram 26), go underneath the railroad tracks and take the first right. You can park your car here and continue on foot. The first half hour is free, after that it costs €2,50 an hour to park.
Coming from the side of the Oostenburgergracht, you go through the Oostenburgervoorstraat (pay attention! you can only enter by bike or on foot) and over the bridge (the gate closes at 8pm). In both cases you follow the pink birdhouses. Can't miss.